Abstract: Marx launched a philosophy revolution of ontology in his Economics Philosophy Manuscript in 1844 and realized the turn to the theory of existence. Based on this philosophical ontology,Marx also made an explanation on the relationship between man and nature from the perspective of ontology,toppling over the traditional metaphysical concept on the relationship between man and nature and enlightening the true relationship between them. A thorough comprehension on this point will not only help us to better understand the path of ontology,but is also of realistic significance.

Key words: ontology, man and nature, Marx, Economics Philosophy Manuscript in 1844